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This normal ER morphology is disrupted when Tat induces the UPR and as a result, the ER becomes dilated, with detached ribosomes no longer in apposition to the ER membrane (Figure 3B, G, H).
In particular, photoreceptor morphology is disrupted and several vacuoles are visible.
In mice lacking Wnt5a, interneuron morphology is disrupted in the OB, while cell number and OB architecture remain intact.
If the balance between fusion and fission is disrupted, mitochondrial morphology is disrupted, and thus, mitochondrial function is severely impaired.
In initiation of EMT, cell cell adhesion, a key factor in maintaining epithelial morphology, is disrupted, followed by the cytoskeleton of epithelial cells transforming into mesenchyal-like cells (Acloque et al, 2009; Chao et al, 2009).
Interestingly, it has been reported that the t-t morphology is disrupted in a PI3K (phosphoinositide 3-kinase -knockout mouse model [ 3-kinase -knockoutthe expression of JP2 at the protein level was not altered, a population of JP2 was identified that was not co-localized with RyR2, which led the authors to conclude that PtdIns(3-kinase -knockoutred for the correct targeting of JP2.
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PBC morphology was disrupted by TIP, which is attributed to enhanced interactions between inorganic and organic domains.
When the concentration of progesterone increases, the nanofiber surface morphology was disrupted due to the increase in polymer solution viscosity creating difficulty in fiber formation; it is clearly depicted in Fig. 1c, d.
ER morphology was disrupted and ER Ca2+-release as well as ER-mitochondria tethering was decreased in c-FLIP−/− mouse embryonic fibroblasts (MEFs).
At postnatal day 2 (P2), the Dicer1 flox/flox MLR10-Cre lens fiber morphology was disrupted, and lens epithelium was diminished on the basis of reduced expression of E-cadherin.
TJs morphology was disrupted and irregularly distributed in the mucosa of 1 out of 8 controls and in 14/31 PD patients.
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morphology is studied
morphology is seen
morphology is investigated
morphology is observed
morphology is graded
morphology is shown
morphology is developed
morphology is described
morphology is obtained
morphology is generated
morphology is considered
morphology is influenced
morphology is labeled
morphology is presented
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