In this study, properties of aggregates of human synovial MSCs were analyzed from the standpoints of morphology, gene profile and in vitro chondrogenic potential.
Recently introduced 3D cell culture techniques showed the significant impacts of the 3D tumor structure on cellular microenvironments on cell growth, cell morphology, gene profile, and drug sensitivities.
Unlike breast cancer, where patients with germline mutations in BRCA1 or BRCA2 have cancers that are distinct from sporadic breast cancers on the basis of morphology or gene profiling [ 28- 30], ovarian cancers with germline BRCA1 or BRCA2 mutations are indistinguishable from their sporadic counterparts [ 11, 23, 31- 33].
Seven-day old linker-engineered spheroids exhibited characteristics of mature MCTS, including spheroid morphology, gene expression profile, cell-cell interaction, extracellular matrix secretion, proliferation and oxygen concentration gradients, and cellular functions.
Meanwhile, reprogramming of diverse somatic cell types of various mammalian species into iPS cells with proliferation, morphology, gene expression, imprinting and chromatin profiles similar to ESCs has been shown (reviewed in Nishikawa et al. 2008; Amabile and Meissner 2009).
On the basis of the morphology, the dendrogram, and the gene profile analyses, the DMAIII-induced cellular and molecular changes differed from those induced by iAsIII or MMAIII.
The isolates used in the present study were previously confirmed as P. aeruginosa using growth morphology, Gram stain, and API test strips, and their type three secretion gene profile was determined [ 29].
Immune-related gene profile.
Each strain harbored a specific gene profile.
Instead of focusing on individual gene profiles, each time point was treated as a quantitative global phenotype, thereby relating the molecular genetic physiology of the cell population to the gross morphology over developmental time.
