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Neuronal numbers and cellular morphology are abnormal in several brain regions, including the hippocampus and cerebellum.
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The number of postembryonically born neurons in the ventral cord decreased and their axon morphology was abnormal.
However, neither cellularity nor morphology was abnormal in thymi of adult PKBα−/− mice nor in PKBβ−/− and PKBγ−/− neonatal thymi.
It is also well known that the brain morphology is abnormal in schizophrenia.
In both cases, vulval cells invaginate and form finger-like structures, but the overall morphology is abnormal.
Fracture callus morphology was abnormal in the rofecoxib-treated rabbits and torsional mechanical testing showed that fracture healing was impaired.
After 72 hr, OPA1 levels in liver mitochondria were reduced by ∼50%, cristae morphology was abnormal, RCS were reduced, and glutamate/malate RCR was impaired.
Attempts to collect embryos at E12.5 yielded only one double mutant in which limb morphology was abnormal, but retarded development meant digit number could not be reliably ascertained.
The optic nerve head morphology was abnormal with significantly decreased optic disk area, retinal nerve fiber layer thickness, cup area and cup depth in FRMD7 patients (P < 0.0001).
However, gland morphology was abnormal in all tnt-4 (RNAi) animals, consistent with a role for muscle in constraining growth of gland extensions.
(A – F ) Confocal images show that compared to controls (A and D ), the ASP morphology was abnormal under conditions that either knockdown (B ) or stimulate (C ) Notch signaling, or that perturb myoblasts by expression of Rpr (E ) or DlRNAi (F ).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com