Exact(4)
It could be of interest to investigate in a broader study whether such observations can be further correlated to e.g. immunohistochemical analyses of morphology and target expression levels that affect their uptakes to bridge the resolution gap between histochemical and in vivo analyses.
In a separate experiment, NSCs were treated with TGF-β1 (Peprotech, Rocky Hill, NJ) at 10 ng/mL for 96 hr and then tested for MMP secretion, cell morphology, and target gene expression.
The identification of such stereotypic neurons is most commonly based on soma position and size, neurite morphology and target, use of specific neurotransmitters, developmental origin and gene expression, or sub-sets of these criteria (see [ 20]).
One important additional feature exhibited by unipolar neurons of the d-HbL and d-HbM is their distinct axonal terminal morphology and target selectivity for dorsal and ventral domains of the interpeduncular nucleus (IPN) (Gamse et al., 2003; Aizawa et al., 2005; Bianco et al., 2008).
Similar(4)
On MR imaging, superficial neurofibromas tend to be asymmetric, lack fascicular morphology and target-like signal intensity, and are likely to involve skin [34], features that are evident in our case (Fig. 11).
In contrast, variants with single aa exchanges C-terminal of the TMD revealed no alteration in mitochondrial morphology and targeting (Fig. 3D).
However, the difference in the response to the target and non-target cues might also have arisen from the difference in cue morphology and probability (target circle 50% of trials vs. non-target square/triangle, each with 25% of trials).
These findings indicate a novel key role for LKB1 in the development of hepatic morphology and membrane targeting of canalicular proteins.
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