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The combined procedure allows correlating the cell's genome with its natural morphology and precise anatomical position.
FTLD-TDP can be further classified into neuropathological subtypes depending on the distribution, morphology and precise cellular location of inclusions [ 28, 45].
Correlating between a single cell's genome and its' morphology and precise position in the tissue micro-environment may also open new research possibilities in the study of the genetics of various physiological and pathological processes.
While valuable information can be obtained via this approach, the disruption or digestion of tissues carries a disadvantage since it destroys the natural architecture and thus results in loss of information regarding the morphology and precise anatomical position of the isolated cells.
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Furthermore, SISH provides a very good resolution, combining an excellent preservation of tumor morphology and a precise definition of amplified cells with silver coloration.
Thus, efforts have been devoted to developing the stimuli-responsive polymers to be served as drug delivery vehicles, which could undergo a tremendous and reversible transition of morphology and dominate the precise controlled release, and work as a response to the various environmental stimuli, like temperature [4], pH [5], ionic strength [6], and magnetic field [7].
We previously explored the effects of nanoscale surface topography on single-cell- and tissue-level morphology and function with precise control over cell and tissue structure, such as guided migration in response to topographical gradient or self-assembly of anisotropic cardiac monolayers.
Despite such observations suggesting a link between cell morphology and gene expression, the precise mechanism by which this influence occurs remains obscure.
Laser surface scanning is a non-invasive technology which enables the accurate and precise analysis of facial morphology. 1 2 24–26 Owing to its portability, easy application and relatively low cost, this technique is very suitable for epidemiological field studies.
Recent imaging developments based on both tumour morphology and tumour function make correct, precise, and reproducible measurement available.
Herein, we review the major advances in controlling polyethylene morphology through precise control of branch frequency and identity.
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