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Changes of neuronal morphology and neuronal death were reported in mice treated with NPs.
This short review will focus on the contribution the avian embryo has made to our understanding of this fly-like region of the vertebrate brain, in respect of its morphology and neuronal architecture, the cellular and molecular mechanisms involved in establishing and maintaining the segments, and the molecular controls of segmental identity.
Overall, the grafted NS/PCs homed in the host parenchyma showing ramified morphology and neuronal marker expression.
Cell morphology and neuronal characteristics were then analysed in a variation of the Scholl analysis [21] (Figure S2).
Only a few hours of MSC chemical induction using this protocol is sufficient for the acquisition of neuronal-like morphology and neuronal protein expression.
Importantly, the clonally-derived OB2a NS/PCs which had been expanded as neurospheres homed in the host parenchyma showing ramified morphology and neuronal marker expression without generating any tumor (Figs. 3C 3D).
The Salm3−/− brain exhibited normal gross morphology and neuronal numbers, as revealed NeuN (neuronal marker) staining.
In this context, over-expression of AChE-S produces aberrant dendritic morphology and neuronal fragmentation (Sternfeld et al. 2000).
Our recent identification of SNO-Drp1, triggered by oligomeric Aβ, provides a mechanistic link between free radical production, abnormal mitochondrial morphology, and neuronal cell injury in neurodegenerative disorders such as AD.
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Both cell types migrated into various brain regions, and a fraction of them gained a neuronal morphology and expressed neuronal or glial markers.
In parallel, wild type Gro/TLE1 caused a reduction in the number of GFP-positive cells exhibiting a neuronal morphology and expressing neuronal cell markers like type III β-tubulin and NeuN (Fig. 7C and E, cf. bars 1 and 2).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com