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The cellular component was the main axon and the top phenotype associations were abnormal nervous system tract morphology and abnormal corpus callosum morphology.
Mammalian phenotype enrichment analysis (MamPhEA 29 further demonstrated that MafB-regulated genes in retinal ECs were associated with phenotypes such as abnormal vasculature morphology, abnormal vascular EC physiology, abnormal apoptosis, abnormal placenta morphology, and abnormal nervous system morphology (Supplementary Fig. 7).
To investigate the clinical significance of intercellular contact point (ICCP) in four-cell stage human embryos and the effectiveness of morphology and abnormal cleavage patterns in identifying embryos with low implantation potential.
Ectopic expression of gene in Arabidopsis showed different morphology and abnormal flowers containing wrinkled organs (Liu et al. 2008).
Finally, as expected, many genes we identified as expressed in our dataset were linked with the MGI Phenotype categories "cleft palate", "midline facial cleft" "abnormal cartilage morphology" and "abnormal myogenesis" (Table S4E).
Mouse phenotypes associated with the cluster 2 include "abnormal respiratory alveolar morphology and abnormal lipid homeostasis".
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These include abnormal neural plate morphology (PM1029) and abnormal neuron excitability (PM1031).
A sizeable fraction of embryos from mtrm heterozygous females had DNA morphology defects and abnormal spindles during early mitoses (61% normal; Figure 4B), consistent with the slightly reduced hatch rate of these embryos.
Pure inbreeding degeneration in sperm structure may partly include features such as sperm DNA fragmentation [ 67] and sperm morphology abnormalities (abnormal size and shape of the head, midpiece and tail) [ 67- 70].
Semen morphology parameters such as percent normal morphology and percent abnormal heads were also reported here.
Consistent with this model, the loosely organized sarcomeric morphology and the abnormal mitochondrial morphology we observed by TEM are similar to those of more immature cardiomyocytes (Hom et al., 2011).
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