Analysis of cell morphology, cell adhesion, expression of surface markers and phagocytic capacity illustrated that while both VD3 and PMA stimulation induced macrophage differentiation important differences existed in comparison to MDM.
Additionally, the MC3T3-E1 cellshowow better cell morphology, adhesion, spreading, proliferation and expression of alkaline phosphatase on SrMnHA than on HA.
The mechanical properties of the microenvironment affect the morphology, adhesion, motility, and protein expression of many cell types, including myocytes, 2) mesenchymal stem cells, fibroblasts, endothelial cells, 7) neutrophils, 7) and smooth muscle cells.
This study and others provide evidence for the importance of nanoscale topographical cues for both cell function (e.g. cellular morphology, adhesion, motility, proliferation) and gene expression.
HOB cells were seeded on sterilized test surfaces where cell morphology, spreading, actin cytoskeletal organization, and focal adhesion expression were assessed.
We have previously shown that these cells have osteoblastic characteristics such as multipolar morphology, adhesion to plastic surfaces, cellular alkaline phosphatase activity, positive Von Kossa staining, and osteopontin and osteocalcin expression.
The signaling pathways or components play fundamental role in regulating cell morphology, adhesion, and motility.
NPM ALK has been reported to affect cell morphology, adhesion and migration in various cell types.
In summary, nanotopography controls cell morphology, adhesions, and proliferation.
The response to topography in the form of nanodot arrays in the range of 10- to 200-nm has revealed a distinctive pattern, and topography indeed affects cell morphology, density, adhesion, and cytokine expression compared to flat controls.
