Culturing WT hippocampal neurons in astrocytic conditioned media from RTT astrocyte cultures results in aberrant dendritic morphology and a reduced neuronal density, whereas RTT neurons cultured in WT astrocytic conditioned media show normal dendritic morphology, suggesting that MeCP2 regulates the expression of soluble factors that are required for neuronal survival.
CD45 negative osteoclasts display abnormal morphology and have a reduced ability to form multinucleated cells.
The doaA deletion was the only mutant showing a growth defect in all the strains tested, translated into an irregular morphology and reduced sporulation (Figs. 6 and 7).
In summary, our study demonstrates that in diabetes there is a profound change in the inter-lamellar regions of the medial layer of the aorta coupled with an altered morphology and reduced extensibility of fibrillin microfibrils.
Silencing the expression of the fission protein Drp1 in MDA-MB-231 and MDA-MB-436 cells caused mitochondria to assume an elongated morphology and reduced the invasiveness of these cells.
Moreover, Erk2 isoform overexpression induces Ras-induced EMT in MCF-10A cells with a change in morphology and reduced E-cadherin levels [ 33].
Here, meprin β induced a dramatic change in cell morphology and reduced the cell number, whereas meprin α seem to play a role in basal keratinocyte proliferation.
In control NIH-3T3 cells, PID expression had a slight effect on morphology, and reduced invasiveness by about 10% (Fig. 3 and Table S2).
We found LEIGC silencing was associated with features typical of EMT, including the conversion of the cobblestone-like epithelial morphology to spindle-shape mesenchymal morphology, reduced expression of CDH1, and increased expression of snail, slug, twist and zeb.
Therefore, we speculate that the aberrant morphology and reduced virulence of Δ com1 mutant might, in part, be associated with reduced energy level and defective cellular homeostasis.
