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In conclusion, the results presented herein provide new evidence that S. boulardii secretes into the medium fatty acids and 2-phenylethanol, among which capric acid (C10 0) is the most effective in inhibiting essential virulence factors of C. albicans, especially morphological transition and partly adhesion as well as biofilm formation.
However, under some host conditions C. albicans can undergo a morphological transition and can become pathogenic.
The identification of rim20 in our glucose host-pathogen interspecies interaction network in the invasion stage thus indicates that rim20 is pivotal in morphological transition and hyphal formation.
Our results indicate that morphological transition and upregulation of master transcription factors EFG1 and FLO8 occur in parallel, irrespective of epithelial cells.
Furthermore, the authors described that the PTE also exerts an effect on the Ras/cAMP pathway, once after the PTE treatment and the exogenous cAMP restored the yeast-to-hypha morphological transition, and they also concluded that PTE was able not only to inhibit the biofilm formation but also to destroy the maintenance of mature biofilms.
In the latter cases, it is not clear whether changes in the assembled structures (both morphological transition and nanostructure degradation) stems from the cleavage reactions occurring on the nanostructures, or on the individual, unassembled molecules that leads to dissociation of the assembled structures into cleavable monomers.
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Moreover, the effects of different stimuli on their morphological transitions and their corresponding photophysical properties are summarized.
However, the source of most morphological transitions and novelties lies in changes in ontogeny.
Importantly, after attachment, the cells undergo morphological transitions and are still mobile after 4.5 h.
Moreover, several TFs play a critical role in the C. albicans morphological transitions and in biofilm formation [ 10, 23].
What is shown is that changes are associated with morphological transitions and may have been a component of the changes leading to the evolution of these forms.
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