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Thus, the morphological transformation induced by erythrodiol was detectable at 25 µM and maximum at 50 µM, while uvaol response at 25 µM was barely visible.
Although the potential off-target effects of these inhibitors cannot be excluded in these experiments, our results suggest that the morphological transformation induced by the oncogenic Met receptor, and driven by the constitutive activation of Grb2 and Shc signals in IECs, relies, at least in part, on the activation of the Ras/MAPK pathway, but not on PI3K signaling.
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This also indicated that γ → ε transformation was important for transformation induced plasticity effect.
Under certain conditions EGF induces morphological transformation and adhesion independent growth of mouse cells.
Beryllium induces morphological transformation in mammalian cells and enhances viral transformation of mammalian cells.
In a recent study, CCN4 acts in an autocrine manner to accelerate cell growth, induce morphological transformation, increase saturation density, and promote tumorigenesis in normal fibroblasts [ 19].
Several authors have demonstrated that DEHP and its active metabolite MEHP induce morphological transformation of SHE cells [ 27- 29], indicating the carcinogenic potency of the two chemicals.
Thus, it was surprising that in the absence of FAK, v-Src could induce morphological transformation, cell motility, cell polarity and Matrigel invasiveness [ 27, 28], and even enhance the frequency of anchorage-independent growth 5- to 10-fold [ 27].
Oncogenic activation of Met was revealed to induce morphological transformation, E-cadherin down-regulation, and protection against anoikis by mechanisms dependent on Grb2, while Shc was shown to be partly required for enhanced cell growth.
Active general covariance considers the dual point transformations induced by coordinate transformations.
Gefitinib induced a morphological transformation in both HT-29 and Caco-2.
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