A hitherto unexpected variability of spectral and morphological subtypes and topographic patterns of distribution in the various retinas are being revealed.
These additional alterations may vary between the distinct morphological subtypes, and thus cause a differentiation block at different levels in haematopoiesis.
The AMLs are usually of the myelomonocytic (FAB-M4) or monoblastic (FAB-M5) morphological subtypes and sometimes express cell-surface lymphoid markers.
We have shown that there was no difference in ERCC1 expression among various morphological subtypes and also no statistical difference in the clinicopathological variables such as age, sex, tumor size, vascular invasion, pleural invasion, and high-grade histology, suggesting that its expression may be an independent prognostic variable, similar to other studies [ 49, 50].
(Full sample information, including French American British (FAB) morphological subtype [22] and cytogenetic karyotypes are reported in Table S2).
The prognostic value of the full range of PODXL scores (0 4) in relation to RFS and OS, in the entire cohort and by morphological subtype, is shown in Additional file 2. All survival analyses were also performed using a dichotomized variable of score 0 1 vs 2 4, with allover less significant results (data not shown).
Table 1 summarises the informative cases, divided into morphological subtype, showing loss of the respective 1p, 19q, and 10q regions.
Importantly, IBC has no specific histological appearance and as such is not a recognised morphological subtype of invasive breast cancer.
The 6 samples with an additional chromosome 8 (samples n. 53, 55, 65, 72, 75, and 100) did not cluster together and were rather grouped with other samples according to their morphological subtype.
