What we have done with this study is to provide morphological evidence that a nonangiogenic tumour phenotype does exist.
As with the morphological phenotypes, mbnl2 injection alone did not have a significant impact on either spontaneous coiling frequency at 24 hpf or on the touch-evoked swim response at 48 hpf.
The increased susceptibility of lkb1 larvae to Atg5 depletion during development occurred even while the yolk is not yet consumed, suggesting that even though the larvae do not show a morphological phenotype at this embryonic stage, the loss of Lkb1 appears to sensitize them to additional stress.
For instance, down-regulation of most of the rice SUVH members does not induce obvious morphological phenotype, while SDG728 RNAi plants produce deformed seed shape.
Although the Δcas1 strains do not exhibit any morphological phenotype, it seems that cas2 must be antagonistic to cas1.
88.21 embryos first display a morphological phenotype approximately at day 4, as they do not develop fin buds and have a swollen pericardium (Figure 1D versus wildype in Figure 1C).
DVAP null alleles do not exhibit the morphological phenotype associated with postsynaptic downregulation of DVAP.
The ptf1a −/− embryos did not have an obvious morphological phenotype.
gba1−/− and gba1+/− did not develop an overt morphological phenotype during early development.
Cortical neurons and glial cells expressing mutant HSPB8 did not exhibit any obvious morphological phenotype.
