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Due to a morphological continuum between some thymoma subtypes and some morphological overlap between thymomas and TC, a variable proportion of cases may pose problems in classification, contributing to the poor interobserver reproducibility in some studies.
These data suggest that a morphological overlap between BC- and HICAP-like neurons may exist.
Significant morphological overlap between benign and malignant lesions complicates diagnosis, and tumour thickness is not always an accurate predictor of prognosis.
The insights in the molecular pathogenesis of lipomatous tumors show a morphological overlap between ordinary lipomas and well-differentiated liposarcomas in 16/97 (16%) cases.
Since there is considerable clinical and morphological overlap between many of these disorders, however, the reliability and clinical relevance of the current diagnostic criteria need better qualification and validation.
Firm diagnostic criteria for melanoma based on histological features alone are difficult to establish owing to the wide morphological range of melanocytic naevi and significant morphological overlap between benign lesions and malignant melanoma.
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In addition, the morphological overlap seen between CN and cystic partially differentiated nephroblastoma (CPDN) can result in diagnostic dilemmas.
Cell death is a highly dynamic response that may manifest in a spectrum of morphological overlap.
CLL shares a clinical and morphological overlap with Small Lymphocytic Lymphoma (SLL).
The existence of morphological overlaps underscores the need for integrated molecular-morphological approaches to assess cryptic M. tuberculata invasions.
Chromophobe RCC and RO pose a diagnostic challenge as both tumours have morphological overlaps.
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