The ultimate morphological outcome in such a working model would thus depend on an integration of a number of factors, including internalization and recycling events of the key proteins.
Importantly, dysregulation of either process resulted in similar morphological outcomes, which could not be differentiated reliably without additional information on growth dynamics, with potentially significant implications for early cancer diagnosis based on histology.
Altogether, molecular, physiological and morphological outcomes suggest the involvement of vertebrates-like coagulation elements in urochordate immunity, not assigned with vasculature injury.
However, this includes the unparsimonious scenario of a malformation establishing itself in two unrelated marsupial populations, with subsequent highly similar morphological outcomes.
In summary, MTC and MTLn3 cells responded differently to Pa when ExoS-GAP was active but produced similar morphological outcomes when ExoS-GAP was inactive.
The primary outcome measure is fitness, and secondary patient-related outcome measures include fatigue, quality of life, and morphological outcomes.
A deeper understanding of the vast morphological diversity of animal forms can thus only be gained by broader taxon sampling and the consideration in developmental studies of the more terminal ontogenetic events that are ultimately responsible for the final morphological outcomes.
Hypoxia also caused neural crest progenitor apoptosis in early-stage embryos and reduced frontonasal mesenchymal cell proliferation at later stages, suggesting a causal link between hypoxia, rates of growth and morphological outcomes.
This difference in morphological outcome when the cells are treated at the same concentration supports the possibility that the structural difference of drugs can cause different types of cell death, especially in the absence of p53 function.
