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The map proved effective in mapping classical morphological mutations of A. majus.
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As mentioned above, de Vries did not know the chromosomal structure of O. lamarckiana and simply compiled various forms of morphological mutations.
Of course, de Vries (1901 1903) did not have any idea about chromosomal variation, but his study of morphological mutations stimulated other workers to study the chromosomal mutations and their importance in speciation.
The characterization of both TS lethal and TS morphological mutations in the same gene in Neurospora emphasizes the value of traditional mutant hunts.
In agreement with the high proportion of embryo lethality, all M2 families segregated for easily visible morphological mutations (data not shown).
Of over 100 TS mutations represented by Neurospora strains at the Fungal Genetics Stock Center, 56 are non-remedial TS lethal and 13 are TS morphological mutations.
This loss occurred by a morphological mutation affecting wing structure instead of a behavioral suppression of the song.
In an extreme case, a morphological mutation causes males to lack the structures on the forewing that are needed for song; thus, males with this mutation are silent.
Another type of robustness is found by the morphological anomaly induced by mutations of the Hsp90 (Rutherford and Lindquist 1998).
In PD patient fibroblasts, only the morphological effects of mutations in Parkin have been studied so far revealing that the degree of mitochondrial branching was higher than in controls [21].
By directly visualizing morphological changes of infected J774 macrophages, we screened an arrayed F. novicida library of more than 3000 mutants containing two allelic mutations of most non-essential genes [2].
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