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Moreover, the climbing fibre inputs underwent morphological modifications, including a significant reduction in the dimensions of their varicosities.
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These latter morphological modifications include dilatation and changes in shape, basement membrane components and pericyte support (Hickey et al., 2000; Hickey and Fraser, 2003).
After peripheral nerve axotomy, injured motoneurons undergo both morphological and physiological modifications, including dendritic branches retraction [ 1, 2], enhanced brain-derived neurotrophic factor [ 3, 4], c-Fos, and c-Jun expression [ 5, 6], and changes regarding their active and passive electrophysiological properties [ 7– 9].
The morphological changes in apoptotic cells are accompanied by several biochemical modifications, including DNA breakdown, protein cross-linking and protein cleavage which lead to the phagocytic recognition of apoptotic cells by adjacent cells [ 25].
Based on the original ACASA model, we made the improved modifications including four added modules (C4 crop photosynthesis, water stress response of stomatal conductance, crop morphological changes, and heterogeneous root water uptake), and two adjusted calculation procedures (soil evaporation resistance and hydraulic characteristic parameters).
The modifications include small changes.
Suggested modifications included incorporation of phonetics.
The modifications include acetylation, methylation, phosphorylation, ubiquitinylation, sumoylation and ribosylation.
Modifications include DNA methylation, histone modifications and microRNA alterations.
Such modifications include DNA methylation and histone modification.
However, EphA4/Fc treatment caused morphological modifications in the varicosities, including a significant reduction in the length of the major axis (P<0.001, Student's t-test), the ratio between major and minor axis (P<0.001, Student's t-test), the area (P<0.05, Student's t-test) and the perimeter (P<0.01, Student's t-test) (Table 2A).
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