Wild-type embryos that were treated from 70 72 hpf onwards with sunitinib displayed no obvious morphological malformation in the vasculature (Fig. 2G,G′).
A series of morphological malformations occur in Atg7 mutant β cells, including accumulation of ubiquitinated inclusions, enlargement of mitochondria, and distension of the endoplasmic reticulum (Ebato et al., 2008; Jung et al., 2008).
This experimental treatment represents a concentration that is well below the tested concentrations at which zebrafish exhibited mortality, alterations in hatching time, and gross morphological malformations.
A function for mych is supported by the observation that knockdown of its expression causes reduction of known regulatory genes in the branchial arches, such as dlx2a, and ensuing morphological malformations (Fig. 7).
Morphological malformations and underdevelopment were determined as percentage of at stage 40 survived larvae.
Alcohol consumption during pregnancy can result in fetal alcohol spectrum disorder (FASD), a constellation of disabilities including deficient pre- and postnatal growth, morphological malformations of the face and/or brain, and cognitive and behavioral deficits [1].
The occurrence of noticeable morphological malformations at YSR was also monitored.
Lack of azot increases morphological malformations and susceptibility to random mutations and accelerates tissue degeneration.
From this, we conclude that specifically killing those cells selected by the azot promoter is sufficient and required to prevent morphological malformations and provide resistance to UV irradiation.
When tissues become scattered with suboptimal cells, lack of azot increases morphological malformations and susceptibility to random mutations and accelerates age-dependent tissue degeneration.
