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Because breast cancer is a complex disease at the clinical and morphological levels, we also investigated the differences between different breast cancer phenotypes (HR+/Her2-, Her2+er2+, HR-/Her2+).
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To address the effects of reduced secretion at the morphological level, we analyzed tracheal morphology in more detail in γCOP mutants.
To assess regeneration at the morphological level, we analyzed the fibers with centrally located nuclei.
At the morphological level, we found that the cTP ko partially recapitulates the cardiac phenotype of Pitx2 constitutive nulls.
On a global morphological level we could not detect any cell patterning differences between controls and Lis1cko animals in four-week old animals (Supporting Information Fig 4).
In order to quantify the expression differences of RORß and ER81 mRNA observed on the morphological level, we performed real time RT-PCR with another cohort of patients including the same FCD types and controls (for details see Additional file 1: Table S2).
To compare tissue sensitivity/responsivity at the morphological level, we compared responses of hind limb and gill in normal and mutant phenotype sibling tadpoles at the same size and age (age matched) as well as with larger, older normal tadpoles of the same hind limb stage (stage matched) after 7 days of exogenous T3 treatment.
We did not find a connection between genetic and morphological levels of variation when comparing the genetic heterozygosity with coefficients of variation of studied morphological characteristics of particular populations.
Taken together, FMOD administration in adult wound models elicits a similar phenotype to fetal wounds at the molecular, cellular, and gross morphological levels.
Nor are these accounts limited to the physiological or morphological levels.
Different species can respond to global change by developing different mechanisms both at physiological and morphological levels.
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