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Morphological indicators of strong lumbar curvature suggest that Au. sediba was derived in this regard relative to Au .africanus and was more similar to the Nariokotome H. erectus skeleton.
These characteristics of degenerating synapses are widely accepted to be the best early morphological indicators of synaptic degeneration [10], [39], [40] and we did not identify any obvious intermediate states preceding these morphological alterations in our material.
Although our findings reveal no overt morphological indicators of cardiac hypertrophy in dt hearts from 2-week old mice, our gene expression analysis of ANF (upregulated), BNF (unchanged) and SERCA2a (downregulated) would suggest mild cardiac stress in dt hearts from young animals.
The latter is supported by the fact that ER fission has been described in other cell types as a physiological phenomenon [19], [20] and we now report that neuronal ER fission occurs in the absence of morphological indicators of cell damage such as dendritic blebbing or loss of spines.
Two hours after SE supragranular layers appeared almost normal, with only a few morphological indicators of histopathology (i.e.: the perivascular edema in Fig. 5A″), whereas subgranular layers at this early time-point exhibited a severe parenchymal changes and vacuolisation (Fig. 5B″).
We also investigated morphological indicators of ventricular hypertrophy.
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In addition, body size is often considered to be a key morphological indicator of niche in natural populations [ 49, 51].
In our opinion, the thickness of the uterine wall is an inappropriate morphological indicator of disorders from a methodological point of view (Ludwin et al., 2014b, c; Fig. 5).
The finding that a morphological indicator of diagnosis (ventricular volume) provided more explanatory power than diagnosis itself for visuo-motor speed, vocabulary, and executive function suggests that volumetric abnormalities in the disease are more important for cognition than non-morphological features.
This seems reasonable because the relative size of the olfactory bulb compared to the cerebral hemisphere, often used as a morphological indicator of olfactory ability, is considerably smaller in the zebra finch than in the chicken (4 versus 15%, respectively)[ 65].
Interestingly, all four species of the D. melanogaster complex are morphologically very similar except for the shape and size of an elaborate cuticular projection (the posterior lobe) on the male genital arch, a structure that is the only reliable morphological indicator of species identity (Ashburner et al. 2005).
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Justyna Jupowicz-Kozak
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