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MRI remains the morphological imaging modality of choice in localising PCC and extra-adrenal paragangliomas, offering better contrast resolution than CT and without ionising radiation [87].
CT is the predominant morphological imaging modality.
Ultrasound (US) is the morphological imaging modality of choice for the study of thyroid nodules.
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For a long time, biochemical markers results were compared to those obtained by conventional morphological imaging modalities.
Due to relatively slow tumour shrinkage as measured on morphological imaging modalities, a significant percentage of patients will continue to undergo toxic therapy for weeks without benefit.
In particular, according to recent studies (Table 2), both organizations reevaluated the role of tumor markers as an early warning able to highlight those patients at risk to have a recurrence due to clusters of tumor cells undetectable by conventional morphological imaging modalities.
MRI evolves as a third lung imaging modality, combining morphological and functional information.
Magnetic resonance imaging (MRI) is a powerful imaging modality for morphological and functional imaging.
Although CT and MR imaging are still the most important modalities in the diagnosis of PCNSL, modern metabolic imaging modalities other than conventional morphological imaging are increasingly used to improve accurate diagnosis of PCNSL.
In this dual imaging modality, PET images provide information on metabolic activity of lesions, while CT images provide morphological information.
In this pilot study, we used different morphological and functional imaging modalities (i.e., mMRI, CeCT, F-Choline-PET/CT, F-Fluoride-PET/CT, and fused F-Choline-PET/MRI) to prospectively examine a small, homogeneous cohort of 21 PC patients with biochemical recurrence after first-line EBRT.
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