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Fig. 7 Volume differences between manual delineation in morphological images and SPECT image segmentation.
AS was in charge of the patient selection, manual delineation of tumours in morphological images, and manuscript revision.
An illustration of the differences between the VOIs obtained from delineation in morphological images and SPECT images for one of the patients is shown in Fig. 8.
The possible volume differences between morphological images and SPECT images and their clinical implications would be of interest for further studies.
Differences are expressed as the volume differences divided by the volume derived from morphological images and are shown as function of the average volumes derived from SPECT and morphological images.
A perhaps more interesting possible cause for the volume disagreement in patient images, rather than potential methodological limitations, is if the morphological images and SPECT images do not reflect the same underlying volume.
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Fig. 8 Difference for a tumour between a morphological image and SPECT.
PMC gray matter meshes were segmented from each subject morphological image and coregistered using the BrainVoyager QX high-resolution intersubject cortex alignment (see supplementary methods).
Tumour regions of interest (ROIs) were drawn in a morphological image and automatically transferred to maps of cerebral blood flow (CBF), cerebral blood volume (CBV) and permeability (KTrans).
First, unenhanced T1-weighted morphological images with and without fat suppression and T2-weighted images were acquired for orientation.
We found that the percentage of apoptotic cells was 67.4%, 26.8%, 15.2%, 8.5% for the treatment with Cdte QDs + DNR, Cdte QDs, DNR, untreatment, respectively (Figure 4C). Figure 4 Assay of cell apoptosis rate and morphological images: (A) Detection of apoptotic and normal cells by acridine orange staining.
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