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The Δbem1 strain is viable at 23 30°C, but divides at a much slower rate than wild type cells and displays morphological heterogeneity, with morphological defects such as multiple buds and large unbudded cells [39].

The adenomyoepithelial tumours analysed in this series displayed great morphological heterogeneity with variable growth patterns and cytological differentiations.

In particular, in 10% FCS-supplemented DMEM or after only 1-2 days in 2% HS-supplemented medium, the cells, characterised by a high proliferation rate (see the mitotic nuclei percentage in Table 1), showed an extreme morphological heterogeneity with elongated, fibroblast-like cells in a range of sizes together with larger, flat and more polygonal-shaped elements (Fig. 2A).

During subsequent cell culture for biochemical analysis, Pr1A-6 and Pr3A-3 gradualostlostheirir morphological heterogeneity with their cells becoming more like the parent PANC-1 cell, whereas cell clones Pr3A-4, Pr3and, and Pr1A-4 retheird their morphological heterogeneity (Table 1).

The material therefore still retained its morphological heterogeneity with this intermediate severity of treatment, although the normalised average rate constant from the model was increased from 0.01 to 0.04 min-1 and the digestible fraction increased to 70% of total cellulose.

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There was distinct morphological heterogeneity within and between xenografts following the treatment, with clear cell areas markedly reduced following the treatment with trastuzumab and significantly reduced after combination therapy-treated tumours (Faratian et al, 2011).

Often there is marked clinical and morphological heterogeneity within tumors of this grade.

Zirconia coatings with high morphological heterogeneity (nanocrystals with an average size of 45±± 2 nm), moderate hardness (about 4.5 5.5 GPa) and high elastic modulus (about 272 285 GPa) were formed on zirconium surface after abrasive blasting followed by IHT at 1000 °C for 30 s.

Evidence of subclone formation from analyses of harvested cells [ 2, 9] and morphological heterogeneity corresponding with cytogenetic heterogeneity has also been reported by Sandinha et al. [ 11].

Along with the TEM images of serum granulations shown in Fig. 4, the additional images shown in Figure 10 illustrate the marked morphological heterogeneity seen associated with serum granulations (compare Fig. 10 with Fig. 4; note also the typically crystalline morphology of the control commercial preparations of CaCO3, Ca3(PO4)2, and HAP now included as controls in Fig. 10L N, respectively).

While primary cultures of normal epithelium cells of proximal origin present a very homogeneous morphology, significant morphological heterogeneity among clear cell RCC cultures were noted.

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