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RPE cells not only started to express mesenchymal markers, their cuboidal morphology changed to a flattened structure lacking the clear morphological hallmarks of RPE cells such as clear cell junctions, apical microvilli and basal infoldings.
Chromatin condensation and DNA fragmentation, two morphological hallmarks of apoptosis, were investigated by microscopy and gel electrophoresis, respectively.
While LBHI/Ast-HI have been established as morphological hallmarks of mutant SOD1-linked FALS, little is known about the formation of these structures in neurons [6].
Histopathologic studies have revealed that neuronal Lewy body-like hyaline inclusions (LBHI) and astrocytic hyaline inclusions (Ast-HI), are morphological hallmarks of mutant SOD1-linked FALS [24].
Neuronal Lewy body-like hyaline inclusions (LBHI) and astrocytic hyaline inclusions (Ast-HI) containing mutant Cu/Zn superoxide dismutase 1 (SOD1) are morphological hallmarks of familial amyotrophic lateral sclerosis (FALS) associated with mutant SOD1.
Apparently, the onset of caspase activation and PARP-1 inactivation in SKOV-3 ovarian cancer cells by Fe-SP resulted in the morphological hallmarks of apoptosis observed (Fig. 3A).
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Electron microscopic examination has revealed that the morphological hallmark of the Langerhans cell is a unique tennis-racket-shaped organelle, the Birbeck granule.
Noncompaction of the ventricular myocardium (NVM) is the morphological hallmark of a rare familial or sporadic unclassified heart disease of heterogeneous origin.
LHI and LBHI/Ast-HI share the following features: 1) eosinophilic staining with a pale core, 2) SOD1, ubiquitin and ER resident protein (KDEL) positivity and 3) the presence of approximately 15 25 nm granule-coated fibrils, which are morphological hallmark of mutant SOD1-linked FALS.
Fibrosis is the morphological hallmark of chronic renal failure.
The autophagosome is the double membrane vesicle that represents the morphological hallmark of autophagy.
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