In addition to maintenance of membrane integrity, apoptotic cells can be discriminated from viable counterparts based on several morphological hallmarks, including cell contraction, nuclear condensation and fragmentation, and actomyosin contraction-dependent membrane blebbing and apoptotic body formation.
Apoptotic cells can often be discriminated from viable counterparts based on several morphological hallmarks including highly conspicuous nuclear condensation and fragmentation, and frequent appearance of characteristic plasma membrane blebs.
For example, a transmission EM analysis of transplanted human photoreceptors would address, at the ultra-structural level, the extent to which the human cells have acquired the morphological hallmark photoreceptors, including outer segment production.
Once activated, caspases cleave a host of cellular substrates, leading to morphological hallmarks of apoptosis, including DNA fragmentation.
The morphological hallmarks of RA include activation of FLSs; infiltration of inflammatory cells such as T cells, B cells and macrophages in the sublining; hyperplasia of the synovial lining layer; fibrotic deposition; and subsequent formation of the "pannus" [ 16].
Hallmarks include an inscrutable narrative and a mute, questing hero.
Other hallmarks include narcissism, poor judgment, and manipulative behavior.
Other clinical hallmarks include spasticity, respiratory abnormalities, autonomic dysfunctions.
Other hallmarks include xerosis (dry skin) and pruritus, resulting in a vicious itch-scratch cycle.
Clinical hallmarks include progressive muscle wasting, speech and swallowing difficulties, fasciculations, altered reflexes and spasticity.
Distinct from the autophagy deficient Atg7−/− mutants, pathognomonic morphological hallmarks of autophagic vacuolar myopathy (AVM) are observed in Vps15−/− mutants, including elevated creatine kinase plasma levels, accumulation of autophagosomes, glycogen and sarcolemmal features within the fibres.
