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The effect is discussed in terms of the peculiar morphological features induced by enhanced mobility of polymer chains on the Au NPs layer.
However, the morphological features induced by PI were completely different.
Under this situation, most of the molecular and morphological features induced by PI in MCF7 cells were reproduced in cotreated MCF10A cells such as, accumulation of LC3II, increased PKCδ phosphorylation, higher CHOP expression, extensive vacuolization with minor inclusion bodies and higher cell death.
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The morphological features have been fully described [ 3, 6].
The extracts caused significant reduction (p < 0.01) in cell viability and altered cell morphological features by inducing the appearance of autophagic vacuoles, as observed by transmission electron microscopy.
The pan-caspase inhibitor, zVAD, or specific caspase-3 (DEVD) or caspase-8 (IETD) inhibitors prevented morphological features of apoptosis induced by cytokines (Fig. 2.A) and the activation of executioner caspases (Fig. 2.A C), and decreased apoptosis as assessed by the presence of hypodiploid cells (Fig. 2.D, E).
Nonetheless, Liu et al. have characterized the morphological features of cell death induced by Tat-Beclin 1, a form of cell death that can be partially rescued by knockdown of Atg13 or Atg14, as well as 3-methyladenine.
We observed by microscopy that N induced morphological features typical of apoptosis.
ABT-737 dose-dependently induced morphological features of apoptosis in Caki/vector and Caki/Bcl-2 cells (Supplementary Figure S1A).
In our hands, when applied to the culture media, phalloidin failed to induce any morphological features of actin polymerization, while scrape loading alone induced significant confounding cellular stress.
Both uncouplers increased the expression of mitochondrial genes such as Tfam and COXIV while inducing morphological features of quiescent mouse HSCs and abrogating TGF-β signal transduction.
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