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The morphological effects described in the preceding paragraphs can be further understood by considering the crystallization behavior of representative polymers.
To identify the possible active principle(s) responsible for the biological and morphological effects described above, we submitted AEPa to HRESITOF analysis.
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Morphological alterations were observed a few hours after MSC induction following the protocol proposed by Woodbury et al. [9] (figure 1), thus reproducing the effects described previously.
Here diverse morphological effects have been described in response to polyQ-expression, including DNA-fragmentation, damage to respiratory chain complexes, apoptosis like effects, spindle formation defects, mislocalization of septin proteins and altered regulation of the prion state [ PSI+] [ 20, 23– 26].
DOI: http://dx.doi.org/10.7554/eLife.03270.011 Changes in pHi correlated with the progressive morphological defects described above.
These results show that cav-1 knockdown enhances biochemical differentiation of BeWo cells, mirroring its effects on morphological differentiation described in the fusion experiments.
Large catalytic and morphological effects were found.
On the whole, morphological effects predominate over electronic effects.
These morphological effects were not seen with pravastatin.
These morphological effects were associated with improved motor performance.
This bias is greater than the effect of morphological parameters described by Chiaromonte et al[ 10].
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