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While lacking direct evidence, a pathogenic role for NB has nonetheless been suggested for an alarming number of diseases based solely on morphological detection of NB, their staining by antibodies deemed specific for NB, and the demonstrated ability of such particles to propagate in cell-free media [refs. 3] [7; see ref. 11 for a list of diseases that have been linked to NB].
Morphological detection of a single metastasis (brain, adrenal gland, etc).
The largest discrepancies between the groups related to the morphological detection of EBV-infected cells in tissue sections.
The studies are all based on the morphological detection of epithelial cells in BM as demonstrated by specific immunostaining.
Though TUNEL assay is an accepted method of morphological detection of apoptosis in cells and tissues, assessment of apoptosis by an additional method would have been more informative and could have overcome the limitation of this study.
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Would evaluation and comparison of negatives allow morphological detection and dynamic patterns, in order to identify the perpetrator?
We found that the percentage of apoptotic cells was 67.4%, 26.8%, 15.2%, 8.5% for the treatment with Cdte QDs + DNR, Cdte QDs, DNR, untreatment, respectively (Figure 4C). Figure 4 Assay of cell apoptosis rate and morphological images: (A) Detection of apoptotic and normal cells by acridine orange staining.
OCT could also been used as a diagnostic tool of brain disease such as Alzheimer's disease [ 18], through detection of morphological or structural changes at an early stage.
However, these techniques are primarily dependent on the detection of morphological alterations in the liver, and these alterations are usually only detected in advanced or late-stage fibrosis, such as cirrhosis [ 8].
Joseph et al. [2] proposed segmentation of MRI brain images using K-means clustering algorithm along with morphological filtering for the detection of tumor images.
This type of analysis provides a method for the detection of morphological alterations in multiple organs (Johnson et al. 1993), as gills and liver.
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