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Surprisingly, we found no gross morphological deficits in nervous system development in GSK-3β null mice.
Expression of dSpt1 bearing a disease-related mutation induced morphological deficits in synapse growth at the larval neuromuscular junction consistent with a dominant-negative action.
The dendrite morphology analysis that we conducted in SREB2 Tg mice of their differentiated DCX-positive neurons demonstrated distinct morphological deficits in these newly generated neurons.
Thus, a graded lowering of Nrg1 signals in this series of mutants appears to be translated into more and more pronounced reduction in numbers of muscle spindles and into increasingly pronounced severities of morphological deficits in remaining spindles.
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Among the observed morphological deficits of newborn neurons in prion disease, a remarkable decrease in the number of apical dendritic spines could reflect defective connectivity with the main afferent input from the entorhinal cortex.
However, after 3 weeks of E2 treatment, these morphological deficits were greatly ameliorated (Figure 7A D).
Diagrams summarizing morphological deficits.
Furthermore, like the additional deficit model, phonological deficits are not thought to be necessarily causally related to syntactic and morphological deficits.
In this study we explore the impact of a morphological deficit on syntactic comprehension.
However, whether all the morphological and functional deficits in the brains of p73−/− mice arise from these actions of p73 on NSC or whether p73 exerts other independent effects has yet to be established.
Moreover, genetic reduction of phospho-eIF4E rescues aberrant Mmp9 mRNA translation and reverses morphological, synaptic, and behavioral deficits in Fmr1 −/y mice.
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