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Surprisingly, we found no gross morphological deficits in nervous system development in GSK-3β null mice.
Some posit an underlying defect in the 'grammar module.' For instance, Rice and Wexler (1996) attribute SLI individuals' morphological deficits to a missing UG principle, namely, the principle of inflection, and Van der Laly and Stollwerk 1997, attribute some SLI children's difficulty with anaphora to their failure to acquire Binding Theory.
However, after 3 weeks of E2 treatment, these morphological deficits were greatly ameliorated (Figure 7A D).
Diagrams summarizing morphological deficits.
Expression of dSpt1 bearing a disease-related mutation induced morphological deficits in synapse growth at the larval neuromuscular junction consistent with a dominant-negative action.
The dendrite morphology analysis that we conducted in SREB2 Tg mice of their differentiated DCX-positive neurons demonstrated distinct morphological deficits in these newly generated neurons.
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In this study we explore the impact of a morphological deficit on syntactic comprehension.
These results were in agreement with morphological presynaptic deficits.
This variability, from no morphological anterior deficit to severe anterior truncation, is greater with intermediate concentration of inhibitors (50 μM for SB-505124 and 0.5 μM for cyclopamine at stage 4+); it reflects the importance of the quantitative requirement of the level of NODAL and SHH signaling during forebrain development.
We observed that continuous PT treatment of mutant mice for 15 days prevented all morphological and functional deficits produced by bilirubin neurotoxicity, such as alterations in cerebellar morphology (Fig. 6A), and differences in layer thickness (Fig. 6B) and in the number and arborization of PCs (Fig. 6C).
These morphological and functional deficits were observed at sides remote from the burn site.
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