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The principal difference in the mechanical stresses and the resulting relaxation in samples S1 and S2 is also illustrated by a detailed AFM analysis of the typical morphological defects that occurred in the GaN cap layers.
None of the U. maydis septins seem to be essential although the disruption of any septin gene produces morphological defects that are exacerbated with the temperature and show a terminal phenotype at 34°C with more than 90% of cells losing all polarity and lysing.
The Drosophila melanogaster Fragile X model, based on the single Drosophila fragile X mental retardation gene (dfmr1), has proven itself a facile system for understanding aspects of the genetic, molecular, cognitive and morphological defects that affect Fragile X and FXTAS patients (Reviewed in [11]).
We have therefore set to identify other morphological defects that may help explain this apparent contradiction.
Interestingly, all Egfr f24 FSC clones and a subset of early Egfr f24 prefollicle cell clones had severe morphological defects that suggested a loss of cell polarity.
Overexpression of either hbox12 or hd-En severely perturbed DV axis formation, inflicting morphological defects that appeared from the gastrula stage onward.
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Beads-on-a-string (BOS) is a striking morphological defect that was induced solely by the four statins in the library: atorvastatin, lovastatin, rosuvastatin and pravastatin (Fig. 7H K).
Nevertheless, the upregulation of the tip cell specification program is unable to compensate for the sprouting defect in Nrp1 null mutants, arguing for a major morphological defect that prevents proper execution of tip cell behavior.
Here we describe a morphological defect that results from the failure of the anterior epidermis to maintain its proper shape while experiencing an inward-directed pulling force exerted by the developing pharynx (foregut) as it undergoes elongation.
However, it does not restore the morphological defects, suggesting that Marf's function in mitochondrial trafficking is cell autonomous and that the defects in synapse morphology are cell non-autonomous.
Most of the resulting G3Myo5-expressing cells showed no severe morphological defects, indicating that the fusion protein is functional.
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