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Morphological defects, such as structural thickness modulations of lamellae and steps on lamellar crystals of ⩽1 nm height, were obtained.
Morphological defects such as edema, body curvature, delayed growth, decreased heart rate and locomotion were observed for each of the compounds tested, often at sublethal concentrations.
Complementary X-ray tomography experiments suggest that the fatigue behavior of the foams is relatively less sensitive to morphological defects such as missing walls than the quasi-static mechanical properties such as plastic strength.
The Δbem1 strain is viable at 23 30°C, but divides at a much slower rate than wild type cells and displays morphological heterogeneity, with morphological defects such as multiple buds and large unbudded cells [39].
Pax6 heterozygous lenses (Fig. 1B) are smaller compared to the wild type lens (Fig. 1A), exhibit subtle morphological defects such as abnormal lens fiber cells [21], and often develop a persistent corneal-lenticular stalk (Fig. 1B).
Non-lethal mutations in other proteins, such as collagens, cause pleiotropic phenotypes that include defects in locomotion, for example the roller phenotype (helical twisting of the body) [11], gross morphological defects, such as the dumpy phenotype, and a dissociation of cuticular structures (the blistering phenotype) [1].
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Zpbp1-null sperm exhibit typical morphological defects of globozoospermia such as round-headed appearance and the absence of an acrosome [ 17].
One of the characteristic morphological traits of loss-of-function alleles of the sole Arabidopsis heterotrimeric G-protein α subunit, GPA1, and the sole Arabidopsis heterotrimeric G-protein β subunit, AGB1, is round shaped rosette leaves [23] [25], but none of the gcr2, gcl1 and gcl2 single, double and triple mutants displayed such morphological defects (Figure 3).
Knockout of WASP on K562 cells (K562WASKO cells) resulted in several megakaryocytic-related defects such as morphological alterations, lower expression of CD41ɑ, lower increments in F-actin polymerization upon stimulation, reduced CD43 expression and increased phosphatidylserine exposure.
However, visual observation did not show such gross morphological defects (Fig. 5A,B).
This suggests that, besides the presence of different types of single morphological defects, the presence of ensembles of such sites must be taken into account when adsorption properties and surface reactivity of different type of microcrystalline MgO materials are compared.
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