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Scanning electron microscopic studies have revealed that, apart from being spermicidal, the factor could also induce morphological defects on spermatozoa.
Furthermore, in a number of metazoans, the phosphorylation state of UPF1 is regulated by the factors SMG1 and SMG5-7 (Supressor with Morphological defects on the Genitalia, from their originally identification in Caenorhabditis elegans [ 6]), which is required for NMD to take place [ 7].
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Many forms of hereditary deafness are caused by morphological defects of the stereocilia bundles on the apical surfaces of inner ear hair cells, which are responsible for sound detection.
To determine the effect of the morphological defect on synaptic transmission, we recorded ERGs from 5 dpf morphant larvae (n=6) and compared them with uninjected larvae (n=7).
These results indicate that expression of UME6 depends on the expression of EED1 and that the morphological defects of eed1Δ cells may be caused by a down-regulation of UME6 expression.
Here we demonstrate that morphological defects of the notochord in zebrafish can generate congenital-type spine defects.
These screens have identified phenotypes ranging from subtle morphological defects of the ear to cardiac arrhythmias.
To further study the morphological defects of Rac1/Rac3-deficient interneurons and their intrinsic or extrinsic nature, we grew ventrally aggregated YFP+ cells from the MGE on collagen-coated coverslips.
HRTEM images show that significant morphological defects are present on the surface of MgO microcrystals in both cases.
The coatings obtained by thermal spraying can present a large variety of geometrical parameters (thickness, roughness…), of microstructures (constituents, nature of phases…), of mechanical properties (hardness, elastic modulus…) and of morphological defects (cracks, pores…) depending on the spraying conditions.
Germline clones of slmb null alleles have previously been found to cause a low frequency (17%) of morphological defects, but their effects on axis formation were not examined (Muzzopappa and Wappner, 2005).
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