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Nevertheless, the upregulation of the tip cell specification program is unable to compensate for the sprouting defect in Nrp1 null mutants, arguing for a major morphological defect that prevents proper execution of tip cell behavior.
Beads-on-a-string (BOS) is a striking morphological defect that was induced solely by the four statins in the library: atorvastatin, lovastatin, rosuvastatin and pravastatin (Fig. 7H K).
Here we describe a morphological defect that results from the failure of the anterior epidermis to maintain its proper shape while experiencing an inward-directed pulling force exerted by the developing pharynx (foregut) as it undergoes elongation.
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The principal difference in the mechanical stresses and the resulting relaxation in samples S1 and S2 is also illustrated by a detailed AFM analysis of the typical morphological defects that occurred in the GaN cap layers.
None of the U. maydis septins seem to be essential although the disruption of any septin gene produces morphological defects that are exacerbated with the temperature and show a terminal phenotype at 34°C with more than 90% of cells losing all polarity and lysing.
The Drosophila melanogaster Fragile X model, based on the single Drosophila fragile X mental retardation gene (dfmr1), has proven itself a facile system for understanding aspects of the genetic, molecular, cognitive and morphological defects that affect Fragile X and FXTAS patients (Reviewed in [11]).
We have therefore set to identify other morphological defects that may help explain this apparent contradiction.
Overexpression of either hbox12 or hd-En severely perturbed DV axis formation, inflicting morphological defects that appeared from the gastrula stage onward.
Interestingly, all Egfr f24 FSC clones and a subset of early Egfr f24 prefollicle cell clones had severe morphological defects that suggested a loss of cell polarity.
Altered levels of cardiolipin have been shown to promote severe cristae morphological defects that resemble those caused by loss of MICOS (Xu et al., 2006; Acehan et al., 2007).
In contrast to double mutants of fil and other YAB genes, fil single mutants display mainly floral and inflorescence morphological defects that do not reflect merely a loss of abaxial identity.
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