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The morphological consequences of altered gene expression can link gene expression to developmental fate.
These are the morphological consequences of the operation of processes that change the duration of the period of an individual's growth, either starting or stopping it earlier or later than in the ancestor, or by extending or contracting the period of growth.
To investigate morphological consequences of Otx2 knockout, both on RPE cells and on photoreceptor outer segments, we performed electron microscopic analysis of control and mutant retina 10 and 20 days post tamoxifen treatment.
Intriguingly, another report in the current issue of Diabetologia, by Le Bacquer and colleagues [ 16], investigates the functional and morphological consequences of rs7903146 in human islets.
To understand the morphological consequences of the mutation, we first investigated the expression pattern of Pxdn during embryonic development using immunohistochemical studies (Fig. 2).
Morphological consequences of diabetic neuropathy, such as increased total area of the intestinal wall in the small intestine, hypertrophy [ 3] and hyperplasia of the intestinal mucosa [ 4], and an increased number of goblet cells [ 5], are also observed.
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Methodological improvements, including higher field strength and a spectroscopic imaging approach are likely to enhance the value of investigating associations between metabolic response and the morphological consequence of chemotherapy.
Interestingly, the morphological consequence of morpholino knockdown of either ERK-1 or -2 in zebrafish embryos (Krens et al. 2008) resembles those resulting from disturbing COS and chitinase/CLP equilibrium, with impaired trunk and tail formation (Semino and Allende 2000).
Pathology plays a pivotal role in bespoke, hypothesis-driven investigations of mouse models, providing important insight into the morphological consequences and mechanisms of gene function (Schofield et al., 2011).
It has been proposed that large-scale duplication events can have morphological consequences as the presence of four Hox clusters in vertebrates, which suggests two polyploidy events at their root, is associated with diversification of the vertebrate body plan (Ohno 1970; Holland et al. 1994).
Loss of Vret in the soma or germline has strikingly different morphological consequences.
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