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However, all studies to date have investigated derivational processes in which morphological complexity is related to a change in surface form.
Furthermore, even if part (a core) of the gene regulatory network is evolutionarily conserved, one has to explain how an increased morphological complexity is achieved.
The genetic and developmental basis of morphological complexity is one of the most important issues in evolutionary biology [ 1, 2].
They are sporulating organisms whose considerable morphological complexity is interlinked with an extraordinary ability to make diverse secondary metabolites (Chater, 2011; Liu et al., 2013a).
These observations led to the hypothesis that morphological complexity is in part directed by the acquisition of new miRNA families during animal phylogeny [ 6, 7].
Organismal or morphological complexity is often measured by the number of cell types or tissue types (Bell and Mooers 1997; Adami 2002; Hedges et al. 2004).
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Typical bi-material interfaces with different levels of morphological complexity are described in 2D and 3D using both periodic (sinusoidal) and Fourier functions.
Of these, patterns of change involving increases in body size and morphological complexity are the most familiar, and it is not difficult to see why: it is obvious that, on average, organisms today are larger and more complex than they were in the distant past.
We therefore suggest including references to existing biological studies investigating the phenomenon of morphological complexity being correlated with regulatory specialization to support the validity and plausibility of their DGEN model assumptions.
We suggest that the emergence of morphological complexity was underpinned by special features of early actinobacteria, such as polar growth and the coupled participation of regulatory Wbl proteins and the redox-protecting thiol mycothiol in transducing a transient nitric oxide signal generated during physiologically stressful growth transitions.
North American cyprinids show a diverse and complex morphological evolution; this complexity is probably the main reason to consider theses fishes as one of the most taxonomically difficult groups on the continent [ 26].
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