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"The morphological changes we see look similar to those caused by other compounds that make tissue more susceptible to carcinogens," said Suzanne Fenton, an E.P.A. scientist who has written about atrazine.
Four pairs of pictures (Figs. 2, 3, 4 and 5) are presented here to reveal the main morphological changes; we tried to take the pictures from more or less the same distance and angle.
To examine the effects of C60 COOH on mitochondrial morphological changes, we established a cell-based functional screening system using BV-2 cells that stably expressed the DsRed2-mito gene.
To investigate the developmental basis of such morphological changes we documented the ontogeny of Clypeaster subdepressus.
To detect any morphological changes, we examined sections every 200 µm through each pancreas.
Regarding morphological changes, we observed a trend towards increased mitochondrial branching in PD patient cells upon mitochondrial stress.
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The morphological change we observed was consistent with the senescence phenotype described in AURKA- or AURKB-knockdown cells (Kim et al, 2011; Lee et al, 2011).
Consistent with the morphological change, we observed the loss of OCT4 and NANOG expression and upregulation of NESTIN and PAX6 expression in primed human ESCs expanded in serum-free 2i/L medium.
To determine whether the TGFβ-induced morphological changes which we observed in human adult epicardial cells is ALK5 dependent, we incubated cEPDCs with TGFβ in the presence or absence of the ALK5 kinase inhibitor (iALK5), SB431542, and observed that cEPDCs stimulated in the presence of iALK5 preserve their epithelial appearance.
Although studies indicate that these characteristics can have renal damage as the underlying cause, we cannot be sure whether these characteristics are the cause or consequence of morphological changes that we expect to observe in kidney aging (Johnson et al., 2002; Brantsma et al., 2006).
There are also other potential drivers of these morphological changes that we did not measure (e.g., competition or predation pressure from an introduced species).
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