Morphological changes are usually considered as irreversible, but in depression, reversible changes of regional brain volumes were reported (Drevets 2003; Kronmüller et al. 2008; Frodl et al. 2008).
Therefore, molecular imaging using positron emission tomography (PET) could be advantageous in this setting since biological changes usually precede morphological alterations and an early tumour-specific response could be defined.
To gain invasive abilities, cancer cells usually undergo morphological changes termed "Epithelial-to-Mesechymal transition" (EMT).
Early morphological changes in the glomeruli are usually subclinical and asymptomatic prior to the development of albuminuria.
The most common causes are morphological changes in the coronary arteries (coronary artery disease), usually arising from a significant reduction, or cessation, of blood flow in the developed atherosclerotic process [24].
Clinically, the severity of OA is usually graded in accordance with the morphological changes of the cartilage surface (such as degree of roughness and fibrillation) and the histopathological assessment of the tissue sections [ 15, 21].
However, these techniques are generally not able to detect early stage infections as they require morphological changes in the tissues to take place, a feature usually associated with advanced infections [ 44].
Diagnosis of IM using conventional endoscopy is unreliable because IM usually appears in flat mucosa and shows few macroscopic morphological changes [ 3- 5].
Especially in early cases there are usually no pathognomonic markers such as distinct clinical features, specific morphological changes by imaging or typical serological markers.
Morphological changes were observed as soon as 24 h after beginning incubation, and evident differentiation morphology appeared usually after another 24 h.
