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They also display marked morphological changes, progressing from bipolar to multibranched cells generating membranous structures, and probably represent a later developmental stage than Nph-OPC.
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The morphological changes progressed to yield network-like structures and many long processes.
We further hypothesise that these PrPd-initiated morphological changes progress with increasing PrPd accumulation to more complex hypertrophic structures and excess immune complex retention as demonstrated by Ig labelling.
In this framework, the morphological changes progress from aberrant crypt foci (ACF), through adenoma, and finally to carcinoma.
These expression patterns underpin the biological processes of intracellular parasite development, replication and egress with accompanying morphological changes as parasites progress from rings to trophozoites to schizonts.
The cultures displayed morphological changes as the disease progressed.
The compound caused cell cycle arrest in G1 phase, suppression of cells progressing through S phase, morphological changes, disruption of the mitochondrial membrane depolarization potential, induction of apoptotic markers as well as p38 and JNK MAPK activation, DNA degradation, and elevated generation of reactive oxygen species (ROS) in SMS-KCNR NB cells.
There were morphological changes within the bone structure as time progressed (Fig. 5a).
Conclusion: It was concluded that the passive inhalation of cigarette smoke yields important morphological changes in the vocal fold epithelium, which may progress to neoplasia.
Once the larval organs form, the serosa is digested and pigmentation of the head and body progresses, but no other important morphological changes occur in the embryo [ 38].
Axotomized neurons progress through an orderly series of morphological changes, including shrinkage, atrophy, and eventually death, as reported in RSNs after cervical axotomy by several groups.
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