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Likewise, inhibition of HeLa cells proliferation has been accompanied by morphological changes, characteristic of apoptosis: cells have become smaller and the morphology has showed karyopycnosis, when exposed to BE for 24 h, and the effect was a dose-dependent [ 24].
Notably, HAND1-expressing DLD1 cells maintained in Dox progressively displayed morphological changes characteristic of differentiation, including giant cell phenotype, flat and elongated morphology and multinucleate formation, which was not seen in the control.
Basal nitric oxide (NO) activity has a pivotal role in the regulation of glomerular hemodynamics, and in animal experiments, its alteration has been associated with morphological changes characteristic of diabetic nephropathy.
Strikingly, MYC expression coincided precisely with the morphological changes characteristic of PIN (Figure 3).
Ectopic expression of MST1/2 induces striking morphological changes characteristic of apoptosis in both nucleus and cytoplasm.
When the cultured primary hepatocytes were treated with TGF-β1, the cells underwent morphological changes characteristic of EMT (Figure 4B).
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To further confirm that Poly-SNO-HSA induced apoptosis in LY-80 cells, DNA fragmentation, which is a morphological change characteristic of the execution phase of apoptosis, was examined [ 30].
These morphological changes were characteristic of apoptotic cells.
We observed morphological changes with characteristic of obtaining mesenchymal phenotype and losing epithelial feature in HCC cell lines under 1% O2 condition.
Once activated, the executioner caspases cleave key regulatory and structural proteins to produce most of the morphological and biochemical changes, characteristic of this type of cell death.
In vitro, prolonged exposure of colonic cells to DCA induced apoptosis and caused morphological changes that were characteristic of apoptosis [ 10], however, apoptosis resistant clones may be selected after frequent exposure to the cytotoxic bile DCA [ 58].
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