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Strikingly, there was a parallel between ZOL inhibition of cell invasion, the decrease in membrane-associated RhoA and the morphological changes characterised by a disorganisation of actin cytoskeleton, as shown by confocal microscopy.
In contrast, ZOL induced dramatic morphological changes characterised by a cell rounding and a disorganisation of actin cytoskeleton accompanied by a loss of stress fibres formation, which were clearly evidenced by confocal microscopy.
We observed that targeting of TNK2 by siRNA in breast cancer cells resulted in distinct morphological changes characterised by a stellate appearance and an absence of protrusions at membrane edges.
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A role for caspase-mediated proteolysis of structural and adhesion proteins has been suggested in the morphological changes that characterise apoptotic cell death.
Morphological changes can be characterised and quantified by computed tomography (CT), especially by multi-detector CT [ 3].
H&E staining of tumour sections revealed more prominent morphological changes that were characterised by more extensive mucinous differentiation, lower overall cell density, and fewer cancer cells in metronomic gemcitabine-treated tumours compared with their MTD-treated counterparts.
In this study, we have characterised morphological changes induced by maternal deprivation in adult rat cortex.
Longitudinal studies would be helpful to more fully characterise the morphological changes that occur over time in the muscle of people with sarcopenia.
Regenerated CHT from BMIMCl was characterised for its morphological changes as dissolution and regeneration occur.
Oesophagitis is characterised by inflammation and morphological changes to the epithelium including basal zone hyperplasia and elongation of vascular papillae.
Metamorphosis is characterised by rapid and extensive morphological changes [12], [13], accompanied by strong shifts in the expression of genes and proteins at the molecular level [14], [15].
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