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The symbionts within the four animals observed in this study did not exhibit diurnal morphological changes but maintained the coccoid morphology, similar to the coccoid stage of the cultured cells.
In the presence of Cyc, culture of osteoblasts in Matrigel™ is not capable of inducing morphological changes but appears to provoke a proliferative response as evident from the upregulation of Cyclin D3 and cdk4.
The engineered cells did not show any morphological changes, but underwent marked apoptosis after ceramide treatment.
BMP-2 or BMP-2/6 at 10 ng/ml induced morphological changes, but with a delay of 24 h when compared to 100 ng/ml (Figure 1F, 1H).
When the DnaA activator of DNA replication is depleted [21], or when CtrA inactivation is prevented [38], swarmer cells undergo polar morphological changes, but fail to initiate chromosome replication.
These transformed cell lines not only exhibited consistent morphological changes but also acquired altered and distinct gene expression patterns compared with normal BEAS-2B cells and control cell lines (untreated) that arose spontaneously in soft agar.
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Movement or migration is a possible cause in some other cases of rapid morphological change, but most such cases do not have genetic components to help determine this.
Co-transfection of empty pEGFP vector could not rescue DLC1-induced cell morphological change, but cells with dominant active ROCK could overcome the inhibitory regulation from DLC1 (Figure 7A-ii) and even DLC1ΔSAM (Figure 7B-ii) and released cells from DLC1-induced cell shrinkage.
The study by Arif and colleagues, therefore, not only revealed the genetic basis for morphological change, but also provided new insights into a well-characterized developmental GRN.
Development is direct; newly hatched individuals do not pass through morphological changes (metamorphosis) but instead are miniature replicas of their parents.
We have shown that SigA is cytopathic for HEp-2 cells, inducing morphological changes similar to, but less pronounced than, those induced by Pet, a related autotransporter toxin in enteroaggregative E. coli.
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morphological data but
morphological variations but
morphological investigations but
morphological abnormalities but
morphological attributes but
morphological approaches but
morphological measures but
morphological details but
morphological features but
morphological combinations but
morphological properties but
morphological structures but
morphological defects but
morphological criteria but
morphological differences but
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