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After treating these cells with dexamethasone (DEX) and/or RA for 4 days, strong morphological changes became apparent in more than 90% of them, but only in the wtBRG-expressing cells (Fig S3C of Supporting Information).
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During malignant transformation, a tumour might change metabolism before morphological changes become visible on CT or MRI.
The application of biomolecular magnetic resonance imaging becomes increasingly important in the context of early cartilage changes in degenerative and inflammatory joint disease before gross morphological changes become apparent.
Interestingly, tumor-adjacent urothelia also expressed high levels of CXCL1, suggesting that in urothelial components, early molecular changes occur well before morphological changes become evident.
Molecular imaging with positron emission tomography/computed tomography (PET/CT) can detect molecular changes within cancer cells before morphological changes become apparent on conventional anatomical imaging such as standalone CT or magnetic resonance imaging [ 2].
During the progression to a metastatic phenotype, carcinoma cells undergo morphological changes, become motile and acquire the ability to migrate and invade to establish secondary tumours at distant sites.
From 2 dpf, when morphological changes become detectable in Sec13 morphants and mutants (Niu et al., 2012), there is a transition in retinal development where proliferation ceases centrally but continues in the marginal zone.
This dramatic morphological change becomes obvious within 3 h after treatment and represents one of the earlier events induced by MR-4.
Schizophrenia is associated with significant, progressive brain morphological changes which become evident by early adulthood [28].
Mammalian spermatogonia undergo mitosis, meiosis, and some morphological changes to become a fully differentiated sperm in testis.
In fact, senescent cells are metabolically active yet quiescent, acquire widespread morphological changes and become resistant to apoptosis.
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