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In addition to its role as amino acid regulator, the cross-pathway control regulator Gcn4 /CpcA /Cpc-1 has various distinct morphological and pathogenic functions in fungi.
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P. infestans belongs to the lineage of oomycetes that unites diverse saprophytic and pathogenic species that share morphological similarities to true fungi [ 2], yet are closely related to non-pathogenic diatoms and brown algae.
Though some microbes are parasitic and pathogenic, many have developed symbiotic relationships with their hosts.
They may also harbor toxic compounds and pathogenic microorganisms.
Reactive oxygen species (ROS) are important signaling molecules that affect vegetative and pathogenic processes in pathogenic fungi.
Any number of insults, both environmental and pathogenic, can lead to wasting.
Both the latter, despite the considerable morphological and phenotypic similarity with the pneumococcus, are considerably less pathogenic for humans and cause infections mainly in the immunocompromized hosts.
In our study, severe cases of AK in Poland and respective pathogenic isolates were assessed at clinical, morphological, and molecular levels.
Such tumors have morphological and molecular similarities which in turn suggests a similar pathogenic mechanism involved in malignant transformation [ 20, 24].
To provide insight into how the transcriptional program translates into morphological variation and the pathogenic lifestyle, we compared the transcriptional profile of the pathogenic yeast phase and the non-pathogenic mycelial phase of two clinical isolates of Histoplasma.
Although some aspects of the pathogenic development of C. graminicola are well-understood, the molecular basis underlying the fundamental morphological and physiological switches that are indispensable for virulence of C. graminicola is still elusive.
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