The ability of the SCF to enhance morphological alteration and F-actin formation was also abolished by treatment with KMP6 or hesperidin.
Microglial cultures exposed for 24 h to 50% C-CM or 50% LI-CM did undergo morphological transformation into amoeboid cells, as shown by phase contrast microscopy and F-actin staining with phalloidin-TRIC.
Thus, it is indicated that decrease of drebrin and F-actin can occur at the dendritic spines without morphological changes.
In addition to effects on cell growth, adhesion, and motility, ODAM expression in MDA-MB-231 cells yielded cytoskeletal reorganization indicative of morphological reversion towards a more developed, epithelial phenotype, evident as increased vimentin solubility and F-actin rearrangement [ 18].
It exists in two forms: G-actin (monomeric globular actin) and F-actin (polymeric fibrous actin), the form involved in muscle contraction.
In tobacco (Nicotiana tabacum) pollen, actin interacts with NtPLDβ1, and F-actin enhances, while G-actin inhibits, PLDβ1 activity (Pleskot et al., 2010).
F-actin plays a crucial role in composing the three-dimensional cytoskeleton and F-actin depolymerization alters fate choice of mesenchymal stem/stromal cells (MSCs).
In addition, Yap1 and F-actin can regulate each other; accumulation of F-actin activates Yap1, while overexpression of constitutively active Yap1 increases F-actin level (Matsui and Lai, 2013; Moroishi et al., 2015).
Morphological analysis of intestinal cells adhering to collagen I revealed a co-localisation of CD47 and α2 integrins to non-apoptotic membrane blebs enriched in Rho A and F-actin.
3. We replaced "G-actin" with "actin monomers" and "F-actin" with "actin filaments" wherever possible.
