WASP-knockout K562 cells show several megakaryocytic-related defects previously described in mice models and in patients with WAS, including morphological alterations and altered F-actin re-organization on activation with PMA.
Such genetic code manipulation had profound cellular consequences as it exposed important morphological variation, altered gene expression, re-arranged the karyotype, increased cell-cell adhesion and secretion of hydrolytic enzymes.
Along with changes on the morphological level, altered gene transcription and protein expression were detected in MAL-overexpressing mice.
Indeed, Groves (2001), without providing any evident morphological justification, altered his taxonomy of NWMs probably to reflect developments in primate phylogenomics.
The TEM analysis showed that the Li[Ni0.5Mn0.5]O2 electrode went through a considerable morphological change without altering its initial layered structure while the electrode retained its initial discharge capacity even after 50 cycles.
Western blot analysis of cells, which were freshly seeded and reacted to DMOG with morphological alterations, did not alter Rac-1 expression as determined by Western blotting (data not shown), indicative of regulation of Rac-1 activity, but not Rac-1 protein.
It has been found that microstructural refinements and morphological changes alter the Meyer exponent.
3D X-ray computer microtomography (CT) experiments have been performed to assess the microstructure of scaled cellular polysiloxane elastomers and to predict how key morphological features alter as a function of compressive loading.
Morphological effects alter the development of the nervous system, particularly from the prenatal period through childhood.
Cells treated with ZOL showed morphological changes, altering fibroblastic into round-shaped configurations and being less adhesive to a culture plate.
