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Evaluation of nuclear morphology by fluorescence microscopy upon treatment with increasing drug-concentrations revealed Ukrain-triggered morphological alterations that are indicative for apoptotic cell death including chromatin condensation, nuclear shrinkage and fragmentation (Fig. 2a).
It is generally assumed that genomic mutations in components of signaling networks directly or indirectly result in morphological alterations that allow growth advantages [1].
The identification and quantification of morphological alterations that occur in the brain due to neurological disease, development and ageing, is of special interest in brain research.
Histopathological observations in the organs clearly show the cellular and morphological alterations that may be occurring due to increased lipid peroxidation.
Infection translated into morphological alterations that included increased granularity (Figure 2A) and was accompanied by a pronounced decrease in both intracellular and extracellular production of NO that importantly, were effectively reversed by Berberine chloride (Figures 2B, C and E).
We identified a suite of recessive phenotypes of C. intestinalis characterized by morphological alterations that are strikingly reminiscent of the larval anatomy in species belonging to different ascidian families.
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However, there were few studies on the morphological alteration that accompanied the progression of advanced tumor.
Based on these findings, we propose a model of the morphological alteration that accompanies progression of advanced CC (Fig. 7).
Previous reports suggested that the presence of hyperglycaemia and dyslipidemia causes functional and morphological kidney alterations that can induce renal dysfunction [ 15, 16].
Indeed, tumour cells usually undergo several morphological and molecular alterations that ultimately result in increasingly resistant and aggressive tumours.
The execution/degradation phase, which is essentially a post-mortem process, is common to distinct types of apoptosis, meaning that the morphological and biochemical alterations that accompany late-stage apoptosis are independent of the initiating stimulus.
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