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Thus, these results indicate that the BOP-induced morphological alterations seen in the hippocampus and cortex are primarily due to neurodegeneration.
Those parts of the same vessels without CAA appeared to be normal and showed no increase in laminin immunoreactivity (Fig. 10a, arrows), indicating a relationship between CAA and the morphological alterations seen in the SEM analyses (Fig. 7).
Comparing the morphological alterations seen in cultured hippocampal neurons by Shank2 knock-down with the literature, an almost identical effect on spine morphology was noted to the RNAi-mediated knock-down of the PAK3 and ARHGEF6 ID genes (25).
The reduction in pCREB and CREB levels and the morphological alterations seen in hippocampus and ACAd suggest dysfunction of neurons in these areas, which may contribute to cognitive deficits in mental disorders (Genoux et al. 2002; Sanders et al. 2002).
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Exercise training was also able to induce heart morphological alterations not seen in the untrained group.
Moreover, in comparison with lactated Ringer's solution (LR) resuscitation, we demonstrated that HS resuscitation reduces bacterial translocation and lung injury after hemorrhage [ 19], and avoids morphological alterations in bone marrow seen after hemorrhagic shock [ 20].
Brain-imaging studies in humans with FASD also find morphological alterations in many of these brain structures (see Moore et al. 2014 for review), which may vary depending on the specific timing of alcohol exposure.
SEM of biologically treated saw dust revealed the morphological alterations during the delignification process targeting the fiber cell walls rich in lignin.
Although the present study was not designed to investigate the extent to which similar changes in renal MT expression occur during other inflammatory nephropathies, our analyses indicate that the same morphological tubular alterations are seen in AASV glomerulonephritis.
These data were also supported by phase contrast microscopy analysis of hCMEC/D3 cell cultures (see Figure 1B) showing complete and fully confluent cell monolayers devoid of morphological alterations and/or empty spots indicative of cell injury and death.
The morphological alterations above took place during 12 h of treatment with Pb, but no visible injury in other cellular components was seen.
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