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The morphological alterations also occurred similarly without p21Cip1, suggesting that these cyclin-dependent kinases (CDKI) are not required for this TGFβ-effect in primary adult mouse hepatocytes.
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In addition, morphological alterations are also accompanied by an extensive change in their protein profiles.
Morphological alterations can also be produced in adults due to exposure to estrogenic compounds early during ontogeny.
Stress not only induces morphological alterations but also decreases levels of pCREB and CREB in hippocampus and ACAd.
Morphological alterations may also be related to the patient and the cycle characteristics, and may involve most or all oocytes in the cohort.
This data provides evidence that Rho kinase activity was necessary to maintain the DMOG-induced morphological alterations, and also supported the cell-cell adherence within the spheroid.
However, morphological alterations are also critical for plastic changes in synaptic strength, pruning of synaptic connections, and occasional responses to injury or other cues.
Numerous studies suggest that exposure to cigarette smoke leads not only to EC and vascular smooth muscle morphological alterations, but also functional exchanges [ 214– 216] as early events in the pathogenesis of cardiovascular disease induced by cigarette smoking [ 217].
Significant reduction in viability of protoscoleces was observed with all tested strains, the remarkable tegumental damage associated with distinct morphological alterations was also observed, 2(b), 2(c), 2(d), and 2 e)), as compared to the PBS control protoscoleces).
In addition to morphological alteration, we also provided evidence for defective synaptic transmission.
Besides morphological modifications, biochemical alterations also occur in promastigotes during metacyclogenesis.
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