c-Myc-transgenic female mice displayed morphological alterations with varying degree of nuclear atypia, such as bronchiolo-adenomas and bronchiolo-adenocarcinomas.
Recently, we have reported the morphological alteration associated with ELI-positive type invasion.
CA125/MUC16 knockdown was associated with morphological alterations along with decreased surface expression of epithelial markers (E-cadherin, cytokeratin-18) and increased expression of mesenchymal markers (N-cadherin, vimentin).
On the other hand, PEF elicited cardiomyogenic differentiation, which is commensurate with the tube-like morphological alterations along with the upregulation of cardiac specific markers.
However, EV71-infected cells treated with curcumin had no significant morphological alterations compared with the uninfected cells (Fig. 1A).
These observations were made concurrently with morphological alteration during the life-cycle of A. chroococcum SBUG 1484, in which cell bodies shortened, encapsulated and development of cysts occurred.
Lateral plain radiograph shows marked morphological alteration of the heel with irregular lytic areas and concomitant PF thickening (double-head arrow) due to spreading of the infection (a).
However, embryos singly injected either with the human NLSmut- or LC8mut-Pak1 mRNA showed very few morphological alterations, consistent with the view that deleterious effects of Pak1 overexpression on zebrafish morphology and survival depend on nuclear import (Figs. 5A and B).
Similar morphological alterations associated with pyknosis and karyorrhexis (nuclear fragmentation) were observed in cancer cells treated with cytotoxic proteins isolated from the various plant sources [ 27, 28].
The up regulation of the EMT-specific genes is accompanied by morphological alterations consistent with a loosening of cell adhesion within the aggregates and adoption of a mesenchymal-like phenotype (data not shown).
